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Injection & Absorption

Route of administration shapes how a research peptide enters circulation, how quickly it reaches peak concentration, and how long it persists in observable form.

Diagram 01 — Tissue Depth

Where each route deposits the compound

Cross-section showing relative needle depth for subcutaneous and intramuscular routes against the body's tissue layers.

EPIDERMISDERMISSUBCUTANEOUS FATMUSCLESC · 45°IM · 90°SURFACEDEEP TISSUE
Subcutaneous · 45° · into fat layer
Intramuscular · 90° · into muscle

Diagram 02 — Route Comparison

Three primary research delivery routes

RouteDeposit SiteOnsetDurationProfile
SubcutaneousBelow dermis, into fat30–60 minLongSlow, steady release. Most common research route.
IntramuscularInto muscle tissue10–20 minModerateFaster absorption via richer vascular bed.
IntranasalNasal mucosa5–15 minShortBypasses first-pass metabolism. Used for cognitive peptides.

Diagram 03 — Absorption Profile

Plasma concentration over 12 hours

Theoretical first-order absorption + elimination model, normalised so each route's peak = 100%. Visual model only — not dosing guidance.

0%25%50%75%100%0h2h4h6h8h10h12h
Subcutaneous (SC)
Intramuscular (IM)
Intranasal (IN)

Why It Matters

Route of administration is one of the strongest variables in any peptide research design. Subcutaneous delivery produces the flattest, longest curves — ideal for compounds requiring sustained presence. Intramuscular sharpens the peak. Intranasal bypasses first-pass metabolism entirely, making it the route of choice for cognitive peptides like Semax and Selank where rapid central action matters more than systemic exposure.

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